In recent years, lung cancer has become one of the scariest diseases due to its high morbidity and mortality. Are there any breakthroughs in the preclinical and clinical research on the treatment of lung cancer? What are the challenges? What has Shanghai Chest Hospital (SCH), a leading institution in the management of lung cancer, done in this field? With these questions, we interviewed Dr. Shun Lu, a senior physician with rich experiences in the diagnosis and treatment of lung cancer.